منابع مشابه
Meeting the unique challenges of drug discovery for neurodegenerative diseases
Introduction There is a mounting need for therapeutics to effectively treat neurodegenerative diseases. Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis almost all share pathological hallmarks of accumulated misfolded protein, ultimately leading to cellular degeneration and death [1]. There is much to be learned by the success...
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Neurodegeneration is a progressive and irreversible loss of neuronal cells in specific regions of the brain. Alzheimer Diseases (AD) Parkinson Disease (PD) are the most common forms of neurodegenerative diseases in older people. Exosomes are extracellular nanovesicles that have a key role in physiological processes such as intercellular communication, cell migration, angiogenesis, and anti-tumo...
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the human brain is composed of several interconnected, functionally distinct structures and much debate has surrounded the basic question of how these structures evolve. brain development begins in early gestation. between 4 weeks and 9 months, brain undergoes rapid development. there are six stages of nervous system development. brain increases connections between birth and 21 years of age. ab...
متن کاملCeruloplasmin in neurodegenerative diseases.
For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link between Cp and neuropathology has strength...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2011
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-011-0040-4